Short review on Saliva PCR Tests

Saliva PCR testing diagnostic accuracy is similar to nasopharyngeal swab testing


An article on saliva PCR testing was published in “Infection and Drug Resistance” journal by our collective in collaboration with the Department of Laboratory Medicine of Kauno Klinikos and the Department of Infectious Diseases of Lithuanian University of Health Sciences. A good concordance between the NP swab and saliva samples was found. The positive percent agreement was 98.28% (CI 90.76– 99.96%) and negative percent agreement was 98.11% (CI 89.93– 99.95%).

In addition to our results, meta-analyses of SARS-CoV-2 RNA detection with different specimen types have shown that sensitivity and specificity of saliva PCR tests are similar to nasopharyngeal swab tests and no significant difference was found (Nasiri K, Dimitrova A, 2021; Butler-Laporte G et al., 2021). Accordingly, the use of saliva specimen is preferable as no close contact to heathcare personnel is necessary (Nasiri K, Dimitrova A, 2021). Another benefit of saliva PCR test is that it is more appropriate for testing of children and quarantined individuals (Butler-Laporte G et al., 2021).